Growing Pains, Evolution and Progress

Growing Pains

CONTEXT The term growing pains describes a common, benign syndrome of recurrent discomfort that occurs in young children. First described in the 1800s, the etiology of this condition remains unclear. The peak incidence does not correspond to a time of rapid growth. Children typically report bilateral pain in the lower extremities that occurs late in the day or at night. EVIDENCE ACQUISITION T...

Growing pains.

Growing pains.

Background: MeCP2, methyl-CpG-binding protein 2, binds to methylated cytosines at CpG dinucleotides, as well as to unmethylated DNA, and affects chromatin condensation. MECP2 mutations in females lead to Rett syndrome, a neurological disorder characterized by developmental stagnation and regression, loss of purposeful hand movements and speech, stereotypic hand movements, deceleration of brain ...

Growing pains in children

Growing pains are the most common form of recurrent musculoskeletal pains in childhood and are present in 10-20% of children, mainly between the ages of 3-12 years. The diagnosis is based on typical historical clinical characteristics with a normal physical examination. The etiology is still unknown but current theories include low pain thresholds, as in fibromyalgia and local overuse pain that...

Race, Rheumatism and Growing Pains.

A survey of the literature on diseases of children reveals the fact that there is a widely-held opinion that children of one type are more prone than those of other types to rheumatism in its various forms. The description of the incriminated type, however, varies so much with different writers as to make correlation difficult. Further, but few writers quote positive evidence in support of thei...